The renin-angiotensin system and malignancy
نویسندگان
چکیده
منابع مشابه
The renin-angiotensin system and malignancy.
The renin-angiotensin system (RAS) is usually associated with its systemic action on cardiovascular homoeostasis. However, recent studies suggest that at a local tissue level, the RAS influences tumour growth. The potential of the RAS as a target for cancer treatment and the suggested underlying mechanisms of its paracrine effects are reviewed here. These include modulation of angiogenesis, cel...
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Unilateral ureteral obstruction (UUO) is a clinical scenario that leads to obstructive nephropathy. UUO alters the expression of many mediators in the ipsilateral kidney. Renin-angiotensin system (RAS) is involved in UUO. Angiotensin II (Ang II) and angiotensin 1-7 (Ang 1-7) as the main arms of RAS influence kidney function which may alter by UUO. Ang II via Ang II receptor subtypes I (AT1R) ...
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Cancer is the leading cause of death worldwide (World Health Organization). Therapeutic strategies usually involve a combination of surgical ablation, radiotherapy and chemotherapy. Apart from conventional chemotherapy, targeting of the tumour vasculature by vascular disrupting agents or inhibitors of angiogenesis has also been used. Several antihypertensive agents have been used to reduce the ...
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The RAS (renin-angiotensin system) is one of the earliest and most extensively studied hormonal systems. The RAS is an atypical hormonal system in several ways. The major bioactive peptide of the system, AngII (angiotensin II), is neither synthesized in nor targets one specific organ. New research has identified additional peptides with important physiological and pathological roles. More pepti...
متن کاملClinical pathology and treatment of renin-angiotensin system 3. Atherosclerosis and the renin-angiotensin system.
Atherosclerosis is an inflammatory disease characterized by endothelial dysfunction, thereby leading to the accumulation of macrophage-derived foam cells in the vessel wall. Endothelial cells, intimal smooth muscle cells, and leukocytes produce a wide range of inflammatory cytokines, chemokines, and growth factors in the multifactorial process of atherosclerosis. Angiotensin II (Ang II) has bee...
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ژورنال
عنوان ژورنال: Carcinogenesis
سال: 2008
ISSN: 0143-3334,1460-2180
DOI: 10.1093/carcin/bgn171